Publications

  • Paschou P, Stylianopoulou E, Karagiannidis I, Rizzo R, Tarnok Z, Wolanczyk T, Hebebrand J, Noethen MM, Lehmkuhl G, Farkas L, Nagy P, Szymanska U, Lykidis D, Androutsos C, Tsironi V, Koumoula A, Barta C, Klidonas S, Ypsilantis P, Simopoulos C, TSGeneSEE, Skavdis G, Grigoriou M. Evaluation of LIM homeopbox genes LHX6 and LHX8 as candidates for Tourette Syndrome. Genes Brain Behav, 11 (4): 444-451 (PDF).
  • Karagiannidis I, Rizzo R, Tarnok Z, Wolanczyk T, Hebebrand J, Noethen MM, Lehmkuhl G, Farkas L, Nagy P, Barta C, Szymanska U, Panteloglou G, Miranda DM, Feng Y, Sandor P, Barr C, Paschou P. The most common worldwide haplotype across SLITRK1 is associated with Tourette Syndrome in a large sample of families. Molecular Psychiatry 17(7): 665-668  (PDF)
  • Müller-Vahl KR, Cath DC, Cavanna AE, Dehning S, Porta M, Robertson MM, Visser-Vandewalle V; ESSTS Guidelines Group (2011). European clinical guidelines for Tourette syndrome and other tic disorders. Part IV: deep brain stimulation. Eur Child Adolesc Psychiatry 20(4):209-217. (PubMed)
  • Verdellen C, van de Griendt J, Hartmann A, Murphy T; ESSTS Guidelines Group (2011). European clinical guidelines for Tourette syndrome and other tic disorders. Part III: behavioural and psychosocial interventions. Eur Child Adolesc Psychiatry. 20(4):197-207.  (PubMed)
  • Roessner V, Plessen KJ, Rothenberger A, Ludolph AG, Rizzo R, Skov L, Strand G, Stern JS, Termine C, Hoekstra PJ; ESSTS Guidelines Group (2011). European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. Eur Child Adolesc Psychiatry 20(4):173-196. (PDF)
  • Cath DC, Hedderly T, Ludolph AG, Stern JS, Murphy T, Hartmann A, Czernecki V, Robertson MM, Martino D, Munchau A, Rizzo R; ESSTS Guidelines Group (2011). European clinical guidelines for Tourette syndrome and other tic disorders. Part I: assessment. Eur Child Adolesc Psychiatry 20(4):155-171. (PDF)
  • Natalie J Forde*, Ahmad S Kanaan*, Joanna Widomska, Shanmukha S. Padmanabhuni, Ester Nespoli, John Alexander, Juan I. Rodriguez Arranz, Siyan Fan, Rayan Houssari, Muhammad S. Nawaz, Francesca Rizzo, Luca Pagliaroli, Nuno R. Zilhäo, Tamas Aranyi, Csaba Barta, Tobias M. Boeckers, Dorret I. Boomsma, Wim R. Buisman, Jan K. Buitelaar, Danielle Cath, Andrea Dietrich, Nicole Driessen, Petros Drineas, Michelle Dunlap, Sarah Gerasch, Jeffrey Glennon, Bastian Hengerer, Odile A. van den Heuvel, Cathrine Jespersgaard, Harald E. Möller, Kirsten R. Müller-Vahl, Thaïra J. C. Openneer, Geert Poelmans, Petra J. W. Pouwels, Jeremiah M. Scharf, Hreinn Stefansson, Zeynep Tümer, Dick J. Veltman, Ysbrand D. van der Werf, Pieter J. Hoekstra, Andrea Ludolph and Peristera Paschou, 2016. TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome. Frontiers in Neuroscience. doi: 10.3389/fnins.2016.00384
  • Birgitte Bertelsen, Hreinn Stefánsson, Lars Riff Jensen, Linea Melchior, Nanette Mol Debes, Camilla Groth, Liselotte Skov, Thomas Werge, Iordanis Karagiannidis, Zsanett Tarnok, Csaba Barta, Peter Nagy, Luca Farkas, Karen Brøndum-Nielsen, Renata Rizzo, Mariangela Gulisano, Dan Rujescu, Lambertus A. Kiemeney, Sarah Tosato, NAWAZ MS, Andres Ingason, Unnur Unnsteinsdottir, Stacy Steinberg, Pétur Ludvigsson, Kari Stefansson, Andreas Walter Kuss, Peristera Paschou, Danielle Cath, Pieter J. Hoekstra, Kirsten Müller-Vahl, Manfred Stuhrmann, Asli Silahtaroglu, Rolph Pfundt, and Zeynep Tümer., 2016. Association of AADAC Deletion and Gilles de la Tourette Syndrome in a Large European Cohort. Biological psychiatry 79.5 (2016): 383-391. doi: 10.1016/j.biopsych.2015.08.027
  • Paschou, P., Drineas, P., Yannaki, E., Razou, A., Kanaki, K., Tsetsos, F., Padmanabhuni, S.S., Michalodimitrakis, M., Renda, M.C., Pavlovic, S. and Anagnostopoulos, A., 2014. Maritime route of colonization of Europe. Proceedings of the National Academy of Sciences, 111(25), pp.9211-9216. doi: 10.1073/pnas.1320811111
  • Nazaryan, L., Bertelsen, B., Padmanabhuni, S.S., Debes, N.M., Have, C.T. and Tümer, Z., 2015. Association study between CDH2 and Gilles de la Tourette syndrome in a Danish cohort. Psychiatry research, 228(3), pp.974-975. doi: 10.1016/j.psychres.2015.05.010
  • Tsetsos, F., Padmanabhuni, S.S., Alexander, J., Karagiannidis, I., Tsifintaris, M., Topaloudi, A., Mantzaris, D., Georgitsi, M., Drineas, P. and Paschou, P., 2016. Meta-Analysis of Tourette Syndrome and Attention Deficit Hyperactivity Disorder Provides Support for a Shared Genetic Basis. Frontiers in Neuroscience, 10. doi: 10.3389/fnins.2016.00340
  • Padmanabhuni, S.S., Houssari, R., Esserlind, A.L., Olesen, J., Werge, T.M., Hansen, T.F., Bertelsen, B., Tsetsos, F., Paschou, P. and Tümer, Z., 2016. Investigation of SNP rs2060546 immediately upstream to NTN4 in a Danish Gilles de la Tourette syndrome cohort. Frontiers in Neuroscience, 10. doi: 10.3389/fnins.2016.00531
  • Karagiannidis, I., Tsetsos, F., Padmanabhuni, S.S., Alexander, J., Georgitsi, M. and Paschou, P., 2016. The Genetics of Gilles de la Tourette Syndrome: a Common Aetiological Basis with Comorbid Disorders?. Current Behavioral Neuroscience Reports, 3(3), pp.218-231. doi: 10.1007/s40473-016-0088-z
  • Luca Pagliaroli, Andrea Vereczkei, Shanmukha Sampath Padmanabhuni, TSGeneSEE, Peristera Paschou and Barta Csaba. Analysis of genetic variation altering microRNA binding site in candidate genes of Tourette Syndrome. The World Journal of Biological Psychiatry (in submission)
  • Pagliaroli Luca, Veto Borbala, Aranyi Tamas and Barta Csaba. From genetics to epigenetics: new perspectives in Tourette Syndrome research. Front. Neurosci. - Child and Adolescent Psychiatry 6 June 2016. doi:10.3389/fnins.2016.00277
  • Aas M, Blokland GA, Chawner SJ, Choi SW, Estrada J, Forsingdal A, Friedrich M, Ganesham S, Hall L, Haslinger D, Huckins L, Loken E, Malan-Müller S, Martin J, Misiewicz Z, Pagliaroli L, et al  Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014. 2016 Feb;26(1):1-47. doi: 10.1097/YPG.0000000000000112. PMID: 26565519
  • Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM. Reduced expression of MYC increases longevity and enhances healthspan. Cell. 2015 Jan 29;160(3):477-88. doi: 10.1016/j.cell.2014.12.016. Epub 2015 Jan 22.PMID: 25619689
  • Ciobanu, Liliana G, Ori Anil PS, Pagliaroli Luca, Polimanti Renato, Spindola Leticia M, Vincent John B, Cormack Freida K Summaries of Plenary and Selected Symposia Sessions at the XXIV World Congress of Psychiatric Genetics, Jerusalem, Israel, October 30 – November 3, 2016, Psychiatric Genetics (Accepted)
  • Luca Pagliaroli, Andrea Vereczkei, Shanmukha Sampath Padmanabhuni, TSGeneSEE, Peristera Paschou and Barta Csaba. Analysis of genetic variation altering microRNA binding site in candidate genes of Tourette Syndrome. The World Journal of Biological Psychiatry (in submission)
  • Arundhuti Das*, Luca Pagliaroli*, Andrea Vereczkei, Eszter Kotyuk, Banrida Langstieh and Csaba Barta. Association of GDNF, CNTNAP2 gene variants with Gambling. (In submission)
  • Nuno R. Zilhão, Dirk J A Smit, Anouk den Braber, Conor V. Dolan, Gonneke A H M, Willemsen Dorret I. Boomsma, Daniëlle C. Cath. Genetic and environmental contributions to stability in adult obsessive compulsive behavior. Twin Research and Human Genetics, 2014. doi: 10.1017/thg.2014.77
  • Nuno R Zilhão · Shanmukha S Padmanabhuni · Luca Pagliaroli · Csaba Barta · Dirk J A Smit · Danielle Cath · Michel G Nivard · Bart M L Baselmans · Jenny van Dongen · Peristera Paschou, Dorret I Boomsma. Epigenome-Wide Association Study of Tic Disorders. Twin research and human genetic, 2015. doi: 10.1017/thg.2015.72
  • A den Braber*, N R Zilhão*, I O Fedko,  J-J Hottenga,  R Pool, D J A Smit, D C Cath, D I Boomsma. Obsessive-compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide SNPs. Translational psychiatry, 2016. doi: 10.1038/tp.2015.223
  • Nuno R. Zilhao, Dirk JA Smit, Dorret I. Boomsma, Danielle C. Cath. Cross-disorder genetic analysis of tic disorders, obsessive compulsive and hoarding symptoms. Frontiers in Psychiatry, 2016. doi: 10.3389/fpsyt.2016.00120
  • Nuno R. Zilhao, Riette Olthof, Dirk J.A. Smit, Danielle C. Cath, Carol A. Mathews, Kevin Deucchi, Dorret I. Boomsma, Conor V. Dolan. Heritability of Tic Disorders: a Twin-Family Study. Psycological Medicine, 2016. doi: 10.1017/S0033291716002981
  • Nuno R. Zilhao, Dorret I. Boomsma, Dirk J.A. Smit, Danielle C. Cath (2017). Genetics of obsessive-compulsive disorder and Tourette’s syndrome. In Andrei C. Miu, Dr Judith R. Homberg and Dr Klaus-Peter Lesch. “Genes, Brain and Emotions: From Resilience to Psychopathology”. Oxford University Press (with editor).
  • Jenny van Dongen, Michel G Nivard, Bart M L Baselmans, Nuno R Zilhão, Lannie Ligthart, BIOS Consortium, Bastiaan T Heijmans, Meike Bartels, Dorret I Boomsma. Epigenome-Wide Association Study of Aggressive Behavior. Twin research and human genetics, 2015. doi: 10.1017/thg.2015.74
  • Bart M L Baselmans, Jenny van Dongen, Michel G Nivard, Bochao D Lin, BIOS Consortium, Nuno R Zilhão, Dorret I Boomsma, Meike Bartels. Epigenome-Wide Association Study of Wellbeing. Twin research and human genetics, 2015. doi: 10.1017/thg.2015.85
  • Alexander, J., Kalev, O., Mehrabian, S., Traykov, L., Raycheva, M., Kanakis, D., et al. (2016). Familial early-onset dementia with complex neuropathological phenotype and genomic background. Neurobiol. Aging. doi: 10.1016/j.neurobiolaging.2016.03.012
  • Alexander J., Drineas P., Paschou P. Variant Ranker: a web-tool to rank genomic data according to functional significance (in submission)
  • Alexander J, Potamianou H, Xing J, Deng L, Karagiannidis I, Tsetsos F, Drineas P, Zsanett T, Rizzo R, Wolanczyk T, Farkas L, Nagy P, Szymanska U, Androutsos C, Tsironi V, Koumoula A, Barta C, Sandor P, Barr C, Tischfield J, Paschou P, Heiman G, Georgitsi M (2016). Targeted re-sequencing approach of candidate genes implicates rare potentially functional variants in Tourette Syndrome etiology. Frontiers in Neuroscience. doi: 10.3389/fnins.2016.00428
  • Anne Rovelet-Lecrux, Kilan Le Guennec, Olivier Quenez, Gal Nicolas, David Wallon, Stphane Rousseau, Anne-Claire Richard, John Alexander, Peristera Paschou, et al (2016). 17q21.31 duplication causes prominent Tau-related Dementia with Increased MAPT Expression. Molecular Psychiatry. doi: 10.1038/mp.2016.226
  • Forde, N.J., Zwiers, M.P., Naaijen, J., Akkermans, S.E.A., Openneer, T.J.C., Dietrich, A.,  Buitelaar, J.K., Hoekstra, P.J.  Basal ganglia structure in Tourette’s Disorder and Attention-deficit/Hyperactivity Disorder. (2016) J Movement Disorders. doi: 10.1002/mds.26849
  • *Naaijen, J., &  *Forde, N.J., Lythgoe, D.J., Akkermans, S.E.A., Openneer, T.J.C., Dietrich, A., Zwiers, M.P., Hoekstra, P.J., Buitelaar, J.K.  Fronto-striatal glutamate in children with Tourette’s Disorder and Attention-deficit/Hyperactivity Disorder. (2016) Neuroimage Clinical. doi: 10.1016/j.nicl.2016.11.013 (*joint first authors)
  • Forde, N.J., Ronan, L, Zwiers, M.P, Alexander-Bloch, A.F., Franke, B., Faraone, S.V., Oosterlaan, J., Heslenfeld, D.J., Hartman, C.A., Buitelaar, J.K., Hoekstra, P.J. Healthy cortical development through adolescence and early adulthood. (in review) Brain Structure and Function
  • Forde, N.J., Ronan, L.,  Zwiers, M.P.,  Alexander-Bloch, A.F., Faraone, S.V., Oosterlaan, J., Heslenfeld, D.J., Hartman, C.A., Buitelaar, J.K., Hoekstra, P.J. No association between cortical gyrification or intrinsic curvature and ADHD in adolescents and young adults. (in review) Frontiers in Neuroscience
  • Openneer, T.JC., Abdulkadir, M., Forde, N.J., Dietrich, A.,Hoekstra, P.J. Internationale samenwerking geeft nieuwe impulsen aan Tourette onderzoek. (2015) Tijdschrift voor psychiatrie
  • Nespoli, Ester, Francesca Rizzo, Tobias M. Boeckers, Bastian Hengerer, and Andrea G. Ludolph. 2016. “Addressing the Complexity of Tourette’s Syndrome through the Use of Animal Models.” Frontiers in Neuroscience 10 (April). doi:10.3389/fnins.2016.00133.
  • Udvardi PT, Nespoli E, Rizzo F, Hengerer B, Ludolph AG. Nondopaminergic neurotransmission in the pathophysiology of Tourette syndrome.Int Rev Neurobiol. 2013;112:95-130. doi: 10.3389/fnins.2016.00133
  • Rizzo F., Abaei A., Nespoli. E., Fegert J. M., Hengerer B., Rasche V., Boeckers T.M. Aripiprazole and Riluzole treatment alters behavior and neurometabolites in a juvenile animal model for ADHD: A longitudinal 1H-NMR spectroscopy study at 11.7 T (submitted)
  • Aripiprazole selectively reduces tics in a juvenile rat model of Tourette’s syndrome and comorbid ADHD – a 1H MRS and behavioral study at 11.7 T Rizzo F., Abaei A., Nespoli. E., Schulze U., Rasche V., Bar-Ghad I., Hengerer B., Boeckers T. M. (in preparation)
  • Effect of psychotherapeutic approaches on cortical and striatal neurochemical profile in a juvenile rat model of ADHD: an in vivo 1H MRS study @ 11.7T Alireza Abaei, Francesca Rizzo, Dinesh K Deelchand, Tobias M. Böckers and Volker Rasche (in preparation)
  • Fan S, Odile A. van den Heuvel, Danielle C. Cath, Ysbrand D. van der Werf, Stella J. de Wit, Froukje E. de Vries, Dick J. Veltman, Petra J. W. Pouwels. Mild White matter Changes in Un-medicated Obsessive-Compulsive Disorder Patients and Their Unaffected Siblings. Front Neurosci. 2016 Jan 11;9:495. doi: 10.3389/fnins.2015.00495.
  • Fan S, Danielle C. Cath, Odile A. van den Heuvel, Ysbrand D. van der Werf, Caroline Schöls, Dick J. Veltman, Petra J. W. Pouwels. Changes in Metabolite Concentrations in Tourette’s Disorder and Obsessive-Compulsive Disorder - A Proton Magnetic Resonance Spectroscopy Study. Psychoneuroendocrinology (Accepted on 8th of Dec, 2016).
  • Fan S, Danielle C. Cath, Ysbrand D. van der Werf, Stella de Wit, Dick J. Veltman, Odile A. van den Heuvel Trans-diagnostic Comparison of Response Inhibition in Tourette’s Disorder and Obsessive-Compulsive Disorde. (In Prep)
  • Fan S, Odile A. van den Heuvel, Danielle C. Cath, Stella J. de Wit, Chris Vriend, Dick J. Veltman, Ysbrand D. van der Werf Altered Functional Connectivity in Resting State Networks· in Tourette’s Disorder (In Prep)
  • Kanaan A.S.*, Gerasch S., Garcia-Garcia I., Lampe L., Pampel A, Anwander A, Near J., Möller H.E.**, Müller-Vahl K.R.** Pathological glutamatergic neurotransmission in Gilles de la Tourette Syndrome. Brain 2017; 140: 218–234. doi: 10.1093/brain/aww285
  • Gerasch S., Kanaan A.S., Jakubovski E. and Müller-Vahl K.R. Aripiprazole improves associated comorbid Conditions in addition to Tics in adult Patients with Gilles de la Tourette Syndrome. Frontiers in Neuroscience 2016; 10: 416. doi: 10.3389/fnins.2016.00416
  • de la Iglesia-Vaya, M., Molina-Mateo, J., Escarti-Fabra, J., Kanaan, A. S., Mart i- Bonmat i, L.: Brain connections – Resting state fMRI functional connectivity. In: Novel Frontiers of Advanced Neuroimaging, S. 51-66, 2013. doi: 10.5772/52273
  • Kanaan A.S.* and Müller-Vahl K.R. Cannabinoid-Based Medicines for the Treatment of Gilles de la Tourette Syndrome. In Press, Handbook of Cannabis and Related Pathologies, Elsevier, 2017. doi: 10.1016/B978-0-12-800756-3.00107-1

 

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