Luca Pagliaroli

Luca Pagliaroli

PhD Student
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry
Semmelweis University
Budapest
Hungary

tel: +36 1 459 1500 ext 60137

fax: +36 1 266 2615
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Project Title:Epigenetic and functional characterization of proposed genetic variants and regions implicated in the pathogenesis of TS and related phenotypes


Short Bio

My name is Luca, I’m 25 from Milan– Italy. In 2010 I obtained a Bachelor’s Degree in Molecular Biotechnology at the University of Milano-Bicocca, then I moved to Bologna, the most ancient university of the Occidental World, where I obtained a Master’s Degree in Pharmaceutical Biotechnology in 2013. Starting from April 2014 I’m working on a project focused on the following three areas: (i) functional characterization of genetic polymorphisms in miR regulated expression of candidate genes in TS; (ii) identification of epigenetic regulatory markers in cell lines and model animals treated with dopaminergic and glutamatergic modulating compounds; (iii) characterization of the whole genome methylation changes possibly involved in the pathogenesis of TS and co-morbid disorders.

Publications

  1. Forde NJ, Kanaan AS, Widomska J, Padmanabhuni SS, Nespoli E, Alexander J, Rodriguez Arranz JI, Fan S, Houssari R, Nawaz MS, Rizzo F, Pagliaroli L, et al (2016) TS-EUROTRAIN: A European-Wide Investigation and Training Network on the Etiology and Pathophysiology of Gilles de la Tourette Syndrome. Front. Neurosci. 10:384. doi: 10.3389/fnins.2016.00384
  2. Pagliaroli Luca, Veto Borbala, Aranyi Tamas and Barta Csaba. From genetics to epigenetics: new perspectives in Tourette Syndrome research. Front. Neurosci. - Child and Adolescent Psychiatry 6 June 2016. doi:10.3389/fnins.2016.00277
  3. Aas M, Blokland GA, Chawner SJ, Choi SW, Estrada J, Forsingdal A, Friedrich M, Ganesham S, Hall L, Haslinger D, Huckins L, Loken E, Malan-Müller S, Martin J, Misiewicz Z, Pagliaroli L, et al Summaries of plenary, symposia, and oral sessions at the XXII World Congress of Psychiatric Genetics, Copenhagen, Denmark, 12-16 October 2014. 2016 Feb;26(1):1-47. doi: 10.1097/YPG.0000000000000112. PMID: 26565519
  4. Zilhão NR, Padmanabhuni SS, Pagliaroli L, Barta C; BIOS Consortium, Smit DJ, Cath D, Nivard MG, Baselmans BM, van Dongen J, Paschou P, Boomsma DI. Epigenome-Wide Association Study of Tic Disorders. Twin Res Hum Genet. 2015.
  5. Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM. Reduced expression of MYC increases longevity and enhances healthspan. Cell. 2015 Jan 29;160(3):477-88. doi: 10.1016/j.cell.2014.12.016. Epub 2015 Jan 22.PMID: 25619689
  6. Ciobanu, Liliana G, Ori Anil PS, Pagliaroli Luca, Polimanti Renato, Spindola Leticia M, Vincent John B, Cormack Freida K Summaries of Plenary and Selected Symposia Sessions at the XXIV World Congress of Psychiatric Genetics, Jerusalem, Israel, October 30 – November 3, 2016, Psychiatric Genetics (Accepted)
  7. Luca Pagliaroli, Andrea Vereczkei, Shanmukha Sampath Padmanabhuni, TSGeneSEE, Peristera Paschou and Barta Csaba. Analysis of genetic variation altering microRNA binding site in candidate genes of Tourette Syndrome. The World Journal of Biological Psychiatry (in submission)
  8. Arundhuti Das*, Luca Pagliaroli*, Andrea Vereczkei, Eszter Kotyuk, Banrida Langstieh and Csaba Barta. Association of GDNF, CNTNAP2 gene variants with Gambling. (In submission)

Conference Presentations

  1. “MicroRNA regulation of candidate genes for Tourette syndrome” Luca Pagliaroli, Andrea Vereczkei, Shanmukha Sampath Padmanabhuni Peristera Paschou and Barta Csaba World Congress of Psychiatric Genetics, 30 October – 3 November 2016, Jerusalem, Israel.
  2. “Effect of chronic treatment with psychiatric drugs aripiprazole and riluzole on DNA methylation changes in the rat striatum and prefrontal cortex” Luca Pagliaroli, Francesca Rizzo, Piroska Devay, Pal Szabo, Tobias Boeckers, Andrea G Ludolph, Csaba Barta and Tamas Aranyi. World Congress of Psychiatric Genetics, 30 October – 3 November 2016, Jerusalem, Israel.
  3. “Changes in DNA methylation profiles followed by sub-chronic treatment with psychiatric drugs aripiprazole and riluzole in the rat striatum and prefrontal cortex” Luca Pagliaroli, Francesca Rizzo, Piroska Devay, Pal Szabo, Tobias Boeckers, Andrea G Ludolph, Csaba Barta and Tamas Aranyi. 2nd Danube Conference on Epigenetics, 5-8 October 2016, Budapest, Hungary
  4. “MicroRNA regulation of candidate genes for Tourette syndrome” Luca Pagliaroli, Andrea Vereczkei, Peristera Paschou and Barta Csaba. ECNP, 17-20 September 2016, Vienna, Austria.
  5. “Epigenetic changes following striatal 6-OH-dopamine lesion and L-DOPA treatment in a rodent tic model” Luca Pagliaroli, Ester Nespoli, Borbala Veto, PiroskaDevay, Bastian Hengerer, Csaba Barta and Tamas Aranyi. European Society for the study of Tourette Syndrome (ESSTS) 2016 Annual Meeting, June 8-11 2016, Warsaw, Poland
  6. “MicroRNA regulation in the 3’ UTR regions of candidate genes for Tourette Syndrome” Andrea Vereczkei, Luca Pagliaroli and Csaba Barta. European Society for the study of Tourette Syndrome (ESSTS) 2016 Annual Meeting, June 8-11 2016, Warsaw, Poland
  7. “Epigenetic changes following striatal 6-OH-dopamine lesion and L-DOPA treatment in a rodent tic model” Luca Pagliaroli, Ester Nespoli, Borbala Veto, Piroska Devay, Pal Szabo, Bastian Hengerer, Csaba Barta and Tamas Aranyi. World Congress of Psychiatric Genetics, 17-20 October 2015, Toronto, Canada
  8. “Studies on epigenetic mechanisms in Tourette Syndrome” Luca Pagliaroli, Andrea Vereczkei, Borbala Veto, Tamas Aranyi and Csaba Barta. 1st world congress on Tourette syndrome and tic disorders, 24-26 June 2015, London, UK
  9. “miRNA regulation of candidate gene in Tourette Syndrome“ Luca Pagliaroli, Andrea Vereczkei, Tamas Aranyi and Csaba Barta. World Congress of Psychiatric Genetics, 12-16 October 2014,Copenhagen, Denmark
  10. “Genetic and epigenetics risk factor in Tourette Syndrome” Luca Pagliaroli, Andrea Vereczkei, Tamas Aranyi and Csaba Barta. Danube Scientific Conference on Epigenetics, 19-21 November 2014, Budapest, Hungary
Attachments:
Download this file (CurriculumVitae_lp.doc)Luca_Pagliaroli_CV[ ]149 kB

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