TS-EUROTRAIN - Projects

Genome-wide search for genes conferring risk of TS (WP1)

Objectives: 1. Identification of SNPs associated with TS. 2. Identification of CNVs associating with TS. 3. Characterization/phenotypic stamp conferred by associated variants. 4. Identification of biological pathways conferring risk for TS.

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Investigation of the role of copy number variations (CNVs) as genetic susceptibility factors involved in pathogenesis of TS and co-morbidity disorders (WP1)

Objectives: The overall aim of the project is to identify genetic susceptibility factors involved in the pathogenesis of TS and co-morbidity disorders, through investigation of rare copy number variations (CNVs) in a unique cohort of 214 deeply-phenotyped Danish patients.

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Gene-environment interactions defining the onset and clinical course of tics and obsessive compulsive symptoms (WP1)

Objectives: 1. Identification of genes and gene pathways for the pathogenesis of tics and obsessive-compulsive symptoms. 2. Identification of gene pathways that affect the clinical course of TS. 3. Exploration of the complex interaction between environment, autoimmunity and genetics related to the onset and clinical course of the disorder spectrum.

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Epigenetic and functional characterization of proposed genetic variants and regions implicated in the pathogenesis of TS and related phenotypes (WP1)

Objectives: 1. Functional characterization of genetic polymorphisms in miR regulated expression of candidate genes in TS. 2. Identify epigenetic regulatory markers in cell lines and model animals treated with dopaminergic and glutamatergic modulating compounds. 3. Characterize whole genome methylation changes possibly involved in the pathogenesis of TS and co-morbid disorders.

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