Integrated genetic networks underlying comorbid TS and OCD (WP2)

Objectives: 1. Detect and integrate common genetic pathways and genetic networks for neurodevelopmental disorders that are genetically related to TS (i.e. OCD and ADHD). 2. Identify common pleiotropic genetic risk variants as possible druggable targets.


The genetic epidemiology of tics and comorbidity with OCD: a genetic epidemiological twin-family study (WP2)

Objectives: 1. To identify the relative contributions of genetic and environmental (family as well as unique) influences to tic and OC symptoms using a twin sample. 2. To estimate quantitative as well as qualitative genetic differences between men and women. 3. To identify interactions between genetic factors and life events on tic occurrence in men and women.


Developing algorithmic prediction models for TS and related disorders (WP2)

Objectives: 1. Develop and apply sophisticated algorithms in order to scan genome-wide datasets of hundreds of thousands of genetic markers and thousands of individuals in order to identify subsets of loci that carry the signature of the disease under study. 2. Develop tools for the estimation of genetic risk for neurodevelopmental disorders. 3. Explore the biological significance and the pathways associated with the selected SNPs by using gene ontology tools.


From genes to brain structure and function in TS (WP2)

Objectives: 1.Identification of cognitive and structural and functional correlates of TS, contrasted against comorbid ADHD and OCD. 2. Assessment of functional implications of TS, OCD, and ADHD risk alleles. 3. Establishment of patterns of multivariate brain activation and connectivity for TS. 4. Performance of multivariate analysis of brain activation patterns to cognitive tasks that takes account of the whole temporal-spatial pattern of activated voxels instead of focusing on predefined regions of interest (ROIs).





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